Computational Stimulation of the Basal Ganglia Neurons with Cost Effective Delayed Gaussian Waveforms

Computational Stimulation of the Basal Ganglia Neurons with Cost Effective Delayed Gaussian Waveforms

Deep brain stimulation (DBS) has compelling results in the desynchronization of the basal ganglia neuronal activities and thus, is used in treating the motor symptoms of Parkinson's disease (PD). Accurate definition of DBS waveform parameters could avert tissue or electrode damage, increase the neuronal activity and reduce energy cost which will prolong the battery life, hence avoiding device r...

Computational models of the basal ganglia.

Computer simulation studies and mathematical analysis of models of the basal ganglia are being used increasingly to explore theories of basal ganglia function. We review the implications of these new models for a general understanding of basal ganglia function in normal as well as in diseased brains. The focus is on their functional similarities rather than on the details of mathematical method...

Brain Stimulation for Basal Ganglia Disorders

The basal ganglia (BG) have long been considered a purely motor region of the brain. However, over the last couple of decades it has progressively become clear that BG are central components of different cortical-subcortical circuits, described on a basic level as ‘motor’, ‘oculomotor’, ‘associative’ and ‘limbic’, according to the function of the cortical regions involved [1]. In turn, each cir...

Emergent basal ganglia pathology within computational models.

Basal ganglia: physiological, behavioral, and computational studies

The basal ganglia has received much attention over the last two decades, as it has been implicated in many neurological and psychiatric disorders, including Parkinson's disease (PD), Attention Deficit Hyperactivity Disorder (ADHD), Tourette's syndrome, and dystonia. Most of current basal ganglia research?in both animals and humans?attempts to understand the neural and biochemical substrates of ...